Gina Lee, Ph.D.
Favorite movie: Begin again
Hometown: South Korea
Non-science activity: Jogging, Drinking wine
Dream benchmate: My current benchmates
One item from your bucket list: Doing nothing
Your scientific interests: Signaling, RNA processing, Cancer metabolism
Current research interests: Understanding how signal transduction pathways control RNA biogenesis and tumor metabolism
In my graduate study with Dr. Jongkyeong Chung at KAIST and Seoul National University, I studied signal transduction pathways using Drosophila in vivo system by identifying and characterizing novel cell growth and metabolism regulators through genetic screens. During my postdoctoral training in Dr. John Blenis lab, I decided to gain insights into the detailed mechanistic aspects of oncogenic signaling pathways. My studies in the Bleins lab have revealed that the growth factor and mTOR signaling promotes glutamine and lipid metabolism in cancers by enhancing mRNA translation and splicing of key enzymes involved in these metabolic processes. I hope my efforts to define the intricate regulation of RNA biogenesis and tumor metabolism by signaling pathways can contribute to the effort to bring better therapies from the bench to bedside.
Honors and Awards
Postdoctoral Fellowship, The Lymphangioleiomyomatosis (LAM) Foundation
Postdoctoral Fellowship, Tuberous Sclerosis Alliance
Postdoctoral Fellowship, Next Generation Research Program, Korean Government
Co-leader, Tri-Institute (Weill Cornell Medicine, Memorial Sloan Kettering Cancer Institute, Rockefeller University) Cancer Metabolism Meeting
Lee G, Zheng Y, Cho S, Jang C, England C, et al., Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling. Cell (2017) 171:1545-1558.
Csibi A*, Lee G*, Yoon SO, Tong H, Ilter D, et al., The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B dependent control of c-Myc translation. Current Biology (2014) 24:2274-2280. *co-first author
Lee G, Blenis J, Akt-ivation of RNA Splicing. Molecular Cell (2014) 53:519-520.
Sun D*, Lee G*, Lee JH*, Kim H, Rhee H, et al., A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nature Structural & Molecular Biology (2010) 17:1188-1194. *co-first author