Jens Hamann, Ph.D.

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Favorite movie: Wedding Crashers

Hometown: Gelnhausen, Germany

Non-science activity: Cooking and tennis

Dream benchmate: Leo Messi

One item from your bucket list: Travel to all the continents

Your scientific interests: Metabolic signaling, cell death, autophagy

Current research interests: Regulation of nutrient-sensing pathways, cellular adaptations to long-term nutrient stresses.

 

Research

I completed my Ph.D. thesis in Mike Overholtzer’s lab at Memorial Sloan Kettering Cancer Center studying cellular responses to nutrient deprivation, focusing on the regulation of cell death pathways induced by nutrient stress. We found that upon starvation, cells can engage in a form of cell cannibalism that involves the non-apoptotic cell death program entosis, where ‘loser’ cells within a cancer cell population are taken up and killed by ‘winner’ cells. This competitive behavior allows a subset of cells to obtain nutrients in the absence of other extracellular sources, resulting in increased survival and proliferation under conditions of long-term nutrient stress.

Selected Publications

Hamann, J.C., Surcel, A., Chen, R., Teragawa, C., Albeck, J.G., Robinson, D.N., and Overholtzer, M. (2017). Entosis is induced by glucose starvation. Cell Reports 20, 201-210.

Durgan, J., Tseng, Y.-Y., Hamann, J.C., Domart, M.-C., Collinson, L., Hall, A., Overholtzer, M., and Florey, O. (2017). Mitosis can drive cell cannibalism through entosis. Elife 6, 27134.