Michal Nagiec, Ph.D.
Favorite movie: I don’t have one
Hometown: Warszawa, Poland
Non-science activity: Soccer/Snowboard
Dream benchmate: Living the dream
One item from your bucket list: Ride Valdez
Your scientific interests: How do cells organize and decipher information about themselves and their environment.
Current research interests: I am working to understand how the MAP kinase ERK2 drives trans-differentiation of epithelial cells to a mesenchymal state. ERK2s involvement in EMT is an important contributor to tumor aggressiveness and the rise of metastatic lesions. I aim to understand how ERK2 signaling integrates with other signaling networks to drive aberrant signaling often observed in aggressive tumors.
I did my PhD thesis research in the lab of Henrik Dohlman at the University of North Carolina, Chapel Hill. I was interested in how cells integrate stress and developmental signals to modulate their physiological response. I identified the signaling circuitry that allowed cells to respond and adapt to the stress while putting the developmental program on pause. I also worked closely with the lab of Tim Elston on several projects that bridged experimental and computational approaches to better understand signaling circuits in bakers yeast.
In the Blenis lab I am working to understand how the MAP kinase ERK2 drives trans-differentiation of epithelial cells to a mesenchymal state. ERKs involvement in EMT is an important contributor to tumor aggressiveness and the rise of metastatic lesions. I aim to understand how ERK signaling influences other signaling networks to promote the development of aggressive tumors.
Honors and Awards
2013-2015 Ruth L. Kirschstein National Research Service Award, NIGMS, NIH
2012 Dana-Farber Cancer Institute, Cancer Biology Training Award, NIH
2006-2008 Cell and Molecular Biology (CMB) Training Award, UNC/NIH
Nagiec MJ, McCarter PC, Kelley JB, Dixit G, Elston TC, Dohlman HG. (2015) Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK. Mol Biol Cell, 26(18):3359-71
Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc. Natl. Acad. Sci. USA, 111(21):E2182-90
Lien EC*, Nagiec MJ*, Dohlman HG. (2013) Proper protein glycosylation promotes MAPK signal fidelity. Biochemistry, 52(1):115-24 * denotes equal contribution.
Hao N*, Yildirim N*, Nagiec MJ*, Parnell SC, Errede B, Dohlman HG, Elston TC. (2012) Combined computational and experimental analysis reveals MAP kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell. * denotes equal contribution.
Nagiec MJ and Dohlman HG. (2012) Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genetics, 8(1):e1002437.
Hao N, Nayak S, Behar M, Shanks RH, Nagiec MJ, Errede B, Hasty J, Elston TC, Dohlman HG. (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell, 30(5), 649-56.