Michal Nagiec, Ph.D.

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Favorite movie: I don’t have one

Hometown: Warszawa, Poland

Non-science activity: Soccer/Snowboard

Dream benchmate: Living the dream

One item from your bucket list: Ride Valdez

Your scientific interests: How do cells organize and decipher information about themselves and their environment.  

Current research interests: I am working to understand how the MAP kinase ERK2 drives trans-differentiation of epithelial cells to a mesenchymal state. ERK2s involvement in EMT is an important contributor to tumor aggressiveness and the rise of metastatic lesions. I aim to understand how ERK2 signaling integrates with other signaling networks to drive aberrant signaling often observed in aggressive tumors.

Research

I did my PhD thesis research in the lab of Henrik Dohlman at the University of North Carolina, Chapel Hill. I was interested in how cells integrate stress and developmental signals to modulate their physiological response. I identified the signaling circuitry that allowed cells to respond and adapt to the stress while putting the developmental program on pause. I also worked closely with the lab of Tim Elston on several projects that bridged experimental and computational approaches to better understand signaling circuits in bakers yeast.

In the Blenis lab I am working to understand how the MAP kinase ERK2 drives trans-differentiation of epithelial cells to a mesenchymal state. ERKs involvement in EMT is an important contributor to tumor aggressiveness and the rise of metastatic lesions. I aim to understand how ERK signaling influences other signaling networks to promote the development of aggressive tumors.

Honors and Awards

2013-2015          Ruth L. Kirschstein National Research Service Award, NIGMS, NIH

2012                   Dana-Farber Cancer Institute, Cancer Biology Training Award, NIH

2006-2008          Cell and Molecular Biology (CMB) Training Award, UNC/NIH

Selected Publications

Nagiec MJ, McCarter PC, Kelley JB, Dixit G, Elston TC, Dohlman HG. (2015) Signal inhibition by a dynamically regulated pool of monophosphorylated MAPK. Mol Biol Cell, 26(18):3359-71

Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.  Proc. Natl. Acad. Sci. USA, 111(21):E2182-90

Lien EC*, Nagiec MJ*, Dohlman HG. (2013) Proper protein glycosylation promotes MAPK signal fidelity. Biochemistry, 52(1):115-24  * denotes equal contribution.

Hao N*, Yildirim N*, Nagiec MJ*, Parnell SC, Errede B, Dohlman HG, Elston TC. (2012) Combined computational and experimental analysis reveals MAP kinase-mediated feedback phosphorylation as a mechanism for signaling specificity. Mol Biol Cell. * denotes equal contribution.

Nagiec MJ and Dohlman HG. (2012) Checkpoints in a yeast differentiation pathway coordinate signaling during hyperosmotic stress. PLoS Genetics, 8(1):e1002437.

Hao N, Nayak S, Behar M, Shanks RH, Nagiec MJ, Errede B, Hasty J, Elston TC, Dohlman HG. (2008) Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol Cell, 30(5), 649-56.