http://www.blenislab.org/contact-us daily 0.75 2015-12-11 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587020523007-D217QWPBMTQDPSEYMFD2/20140604-214221.png Contact Us http://www.blenislab.org/john-blenis daily 0.75 2020-04-16 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525038621308-REL5METHQLEEZ7YDUNMM/john.png Dr. John Blenis, Principal Investigator Dr. John Blenis https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525038621308-REL5METHQLEEZ7YDUNMM/john.png Dr. John Blenis, Principal Investigator Dr. John Blenis http://www.blenislab.org/all-publications daily 0.75 2026-02-27 http://www.blenislab.org/alumni daily 0.75 2024-11-05 http://www.blenislab.org/bethany-schaffer daily 0.75 2023-07-27 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075722303-E15WC6ESE5EVRT0DBCC5/Bethany_Schaffer.jpg Bethany Schaffer, Ph.D. - Bethany Schaffer Favorite movie: Arrival Hometown: Louisa, KY Non-science activity: cycling, preferably in Northern California Dream benchmate: a Melinda Gates/Elon Musk hybrid One item from your bucket list: convince John Blenis that mTORC1 is just another downstream effector of AMPK Your scientific interests: countering anthropogenic climate change so that cell signaling still matters in the future Current research interests: understanding ERK2-driven regulation of protein transport in cancer progression https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075722303-E15WC6ESE5EVRT0DBCC5/Bethany_Schaffer.jpg Bethany Schaffer, Ph.D. - Bethany Schaffer Favorite movie: Arrival Hometown: Louisa, KY Non-science activity: cycling, preferably in Northern California Dream benchmate: a Melinda Gates/Elon Musk hybrid One item from your bucket list: convince John Blenis that mTORC1 is just another downstream effector of AMPK Your scientific interests: countering anthropogenic climate change so that cell signaling still matters in the future Current research interests: understanding ERK2-driven regulation of protein transport in cancer progression http://www.blenislab.org/long-he daily 0.75 2020-04-16 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075240235-MJIBT216K7Z2T3CW2D0K/Long_He.jpg Long He, Ph.D. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075240235-MJIBT216K7Z2T3CW2D0K/Long_He.jpg Long He, Ph.D. http://www.blenislab.org/michal-nagiec daily 0.75 2023-07-27 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/23937eca-cf08-4212-a126-ad51ebac6c50/michal.jpg Michal Nagiec, Ph.D https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/23937eca-cf08-4212-a126-ad51ebac6c50/michal.jpg Michal Nagiec, Ph.D http://www.blenislab.org/jennifer-endress daily 0.75 2023-07-25 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587074828480-K5Z0JDHO988W4QEZQEMD/Jenn_Endress.jpg Jennifer Endress https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587074828480-K5Z0JDHO988W4QEZQEMD/Jenn_Endress.jpg Jennifer Endress http://www.blenislab.org/kripa-shobana-ganesh daily 0.75 2020-04-16 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075065866-HCUG63CBLSS9SBXKS1IZ/Kripa_Shobana_Ganesh.jpg Kripa Shobana Ganesh https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075065866-HCUG63CBLSS9SBXKS1IZ/Kripa_Shobana_Ganesh.jpg Kripa Shobana Ganesh http://www.blenislab.org/sungyun-cho daily 0.75 2023-07-25 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/f3b54ea9-2c42-4b96-bad6-e17516928536/sungyun.png Sungyun Cho https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/f3b54ea9-2c42-4b96-bad6-e17516928536/sungyun.png Sungyun Cho http://www.blenislab.org/vi-vien-low daily 0.75 2022-01-31 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075970457-3IZ9NWHW2OWTCY9HWCKV/Vi_Vien_Low.jpg Vi Vien Low https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587075970457-3IZ9NWHW2OWTCY9HWCKV/Vi_Vien_Low.jpg Vi Vien Low http://www.blenislab.org/research daily 0.75 2023-07-27 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524158839118-EDE1S4I85CGEGASCPYOI/IMG_6656.jpg Research https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524158780495-O51AZLH0SUL4BGLKU8DU/reseach.png Research https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525151863798-KDTK2YYLZRKXHGSPWL7L/Logos.jpg Research https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524158780495-O51AZLH0SUL4BGLKU8DU/reseach.png Research https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525151863798-KDTK2YYLZRKXHGSPWL7L/Logos.jpg Research http://www.blenislab.org/sensing-mechanisms-that-regulate-cell-growth daily 0.75 2023-07-27 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524937228372-2SWGKR6CD376Z8KQHAAO/sensingP.png Sensing mechanisms that regulate cell growth https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524936659302-6JKQOI15YN2PAYW41UW4/sesing1.png Sensing mechanisms that regulate cell growth https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524936137372-MCJEF4V6FPMIDR46XBO9/sensin2.png Sensing mechanisms that regulate cell growth https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524936904636-VWWQ1HORSD8LNT5ELB8I/1.2.png Sensing mechanisms that regulate cell growth https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524936659302-6JKQOI15YN2PAYW41UW4/sesing1.png Sensing mechanisms that regulate cell growth https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524936137372-MCJEF4V6FPMIDR46XBO9/sensin2.png Sensing mechanisms that regulate cell growth https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524936904636-VWWQ1HORSD8LNT5ELB8I/1.2.png Sensing mechanisms that regulate cell growth http://www.blenislab.org/understanding-how-signaling-cascades-dictate-cell-fate-decisions daily 0.75 2023-07-27 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524938027838-4I8OSIHGB1TN8RVRGM4M/Article2.png Understanding how signaling cascades dictate cell fate decisions https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524161810474-VHIHXEGB7BEZIFHL5GM1/Screen+Shot+2018-04-19+at+2.15.18+PM.png Understanding how signaling cascades dictate cell fate decisions https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524161842341-ZLUO7U1N0CGYWQUB709L/1.2.png Understanding how signaling cascades dictate cell fate decisions https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524161810474-VHIHXEGB7BEZIFHL5GM1/Screen+Shot+2018-04-19+at+2.15.18+PM.png Understanding how signaling cascades dictate cell fate decisions https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524161842341-ZLUO7U1N0CGYWQUB709L/1.2.png Understanding how signaling cascades dictate cell fate decisions http://www.blenislab.org/metabolic-rewiring-that-fuels-tumorigenesis daily 0.75 2023-07-27 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524938714902-3RLEJPRPN7CKUXETN01Z/article3.png Metabolic rewiring that fuels tumorigenesis https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/ffe14182-b4d1-4ca4-b5d4-9d671d5dfe5b/prop.png Metabolic rewiring that fuels tumorigenesis - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/ffe14182-b4d1-4ca4-b5d4-9d671d5dfe5b/prop.png Metabolic rewiring that fuels tumorigenesis - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://www.blenislab.org/discerning-the-mechanisms-of-initiation-and-progression-of-lam-disease daily 0.75 2020-04-16 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524939101735-MU84HMA8N0207O6ZTC24/article4.png Discerning the mechanisms of initiation and progression of LAM disease https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524940571361-N5RE6NCSVIS6T3X16MQE/Screen+Shot+2018-04-19+at+2.40.36+PM.png Discerning the mechanisms of initiation and progression of LAM disease https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524940571361-N5RE6NCSVIS6T3X16MQE/Screen+Shot+2018-04-19+at+2.40.36+PM.png Discerning the mechanisms of initiation and progression of LAM disease http://www.blenislab.org/news daily 0.75 2025-02-10 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525540707277-J4SWFG54Y9VHRZMIFKB1/IMG_7081.jpg News https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/7278d68f-7fcb-47dd-8d3b-91603c2c7696/Brown+Aesthetic+Modern+Elegant+Fashion+Lifestyle+Newspaper+Blog+Your+Story+%281%29.png http://www.blenislab.org/zhongchi-li daily 0.75 2024-11-05 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587028789887-LVZ2IMJAQS329J8KOCLR/Zhongchi_Li.jpg Zhongchi Li, Ph.D. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587028789887-LVZ2IMJAQS329J8KOCLR/Zhongchi_Li.jpg Zhongchi Li, Ph.D. http://www.blenislab.org/home daily 1.0 2024-11-14 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525063392262-B3HCFZ5HVY2NALJWULAM/Untitled.png Home https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524931991781-E5EA1NMISI03JZP42F9J/IMG_6666.jpg Home - Welcome to the Blenis Lab The Blenis Laboratory investigates how cells sense and integrate cues to maintain cellular homeostasis. Particularly, we are interested in understanding how cellular signaling and metabolism are hijacked by cancer cells to promote tumorigenesis and drug resistance. We are also investigating the links between aging (and other metabolic diseases such as obesity and diabetes) on cancer initiation and progression. Utilizing state-of-the-art technologies, we observe and manipulate these pathways in a variety of cell-based and mouse models of cancer. Clinician-scientists in the lab then translate our findings in the clinic. Additionally, we have also established several collaborations with clinicians at New York-Presbyterian Hospital and Weill Cornell Medicine (WCM). The Blenis Laboratory is a part of the Meyer Cancer Center at WCM, a newly established cancer center in the heart of NYC. Dr. Blenis is the Anna-Maria and Stephen Kellen Professor in Cancer Research, Associate Director for Basic Science at the Meyer Cancer Center, Professor of Pharmacology at WCM and the graduate program director for the Department of Pharmacology. Dr. Blenis is affiliated with Tri-Institutional training programs (centered among three premier New York Institutions: Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and the Rockefeller University), and is a participating member of the Tri-Institutional PhD program in Chemical Biology and the Tri-Institutional MD-PhD Program. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674595111433-VYYUGNTQYC9TFNF5VGOM/long%252Bet%252Bal_pnas.jpg Home https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674595139691-EX6LMZXNLF5Q6M1YMIT6/Zhongchi-paper.jpg Home https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674595781109-89BDPCGMZQ4GK1WM8FM7/Lee-pub.jpg Home https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674595381411-AMH24R8H0MDABPFERNT6/Gomes-pub.jpg Home http://www.blenislab.org/publications daily 0.75 2023-04-05 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1680697993605-AN3ARLUUJ6C3TAHMS6CT/PubFig.jpg Publications https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525065330205-ES2UWLV6HJMPGSNQVY6N/IMG_6709.jpg Publications https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525064187847-EM57ZS9M3OZ6IA6OSL0P/IMG_6709.jpg Publications http://www.blenislab.org/lab-events daily 0.75 2025-07-08 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587021675025-RULHLQDCN7ZCNS3EXQVF/IMG-0706.png Lab Events https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674761742362-23U38URPD51MKGSS2V2H/labretreat.jpg Lab Events - Lab retreat 2022! https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674762189410-GJUX869MGGLQE5819VLE/holidasy.jpg Lab Events - Holiday celebrations! https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586333173958-GG6M0TJ5533SR8UF3WDY/IMG-3157.JPEG Lab Events Who said lab photos need to be serious? January 2020 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586333170645-YPZ8LPVLGM5AGOAAWTGA/IMG-3155.JPEG Lab Events Lab photo January 2020 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674762448366-TNL3QP1X76G92LUIEJ7A/nikos-xmas.jpg Lab Events - Nikos won big at gift exchange! https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674762684078-UT3GRWRAUESFK0C6CZUM/PHOTO-2022-08-16-13-12-08+2.jpg Lab Events - Ice cream outing! (Thanks NYP) https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674762712346-QZC4MXQ9H4CV8LKY9ZIT/PHOTO-2022-09-13-18-54-39.jpg Lab Events - More retreat 2022! https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586321766889-SUNMQM87NS9A0BR29AHU/IMG-4499.jpg Lab Events Blenis Lab bonding time August 2019 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586333175611-K831UB4CE9MM9K3M29RB/IMG-8188.JPG Lab Events We like Halloween October 2019 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586321764714-Q1ENJGTBKV3W8IE38SVP/IMG-4515.jpg Lab Events We love to dance… (Especially John) August 2019 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586321762090-D6QZK1H8TVMXYGE00GDC/IMG-4391.jpg Lab Events Birthdays are always festive in the Blenis lab. Happy birthday Kripa! August 2019 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586321759841-KPLNY43JL2E92SR7OG1H/IMG-0020.jpg Lab Events We can watch the NYC marathon from the lab. November 2018 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525144844776-MWWM6GGDD966ZQD0FXFG/1.jpg Lab Events Feeling the holiday cheer (left to right) Tanya Schild, Vivien Low, Didem Ilter, Tasnia Islam, Ana Gomes, Kripa Ganesh, Bethany Shaffer December 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525144912499-6636R6B43ZQ7IQAM0GCE/2.jpg Lab Events The postdoc mentor and student mentee relationship is one to celebrate. (left to right) Bethany Schaffer, Kripa Ganesh (back, gracefully fleeing) Bethany’s husband, Alexander LaFortune December 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525144912309-R65FLTACMJREX8WO4TCT/3.jpg Lab Events Our technicians are the indispensable workforce of the lab! (left to right) Adam Rosenzweig, Tasnia Islam December 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145065078-E1JY7MJ3KABF6PBIVVN5/4.jpg Lab Events Cheers to a happy lab (left to right) John Blenis, Ana Gomes, Edouard Mullarky, Joana Nunes, Andreas Lamprakis, Yasir Ibrahim, Ander Mutvei, Yihung Ou November 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145064941-SM40K0ZMPWLZ81I2L96Y/5.jpg Lab Events The lab is flame retardant but the wilderness is a different matter (left to right) Sungyun Cho, Andre Chavez, Kripa Ganesh, Tanya Schild September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145067115-IJVVL1GALVWZFYWIW9AG/6.jpg Lab Events Telling lab legends over s’mores and a campfire (left to right) Edouard Mullarky, Joana Nunes, Sungyun Cho, Bethany Schaffer, Kripa Ganesh, Tanya Schild, Michal Nagiec, John Blenis September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145279938-NCFP1JYMLN2C6423GIEY/7.jpg Lab Events Pillars of a solid labfam (back row, left to right) John Blenis, Edouard Mullarky, Ana Gomes, Didem Ilter, Andreas Lamprakis, Adam Rosenzweig, Andre Chavez, Michal Nagiec (front row, left to right) Kripa Ganesh, Bethany Schaffer, Tanya Schild, Tasnia Islam, Vivien Low, Joana Nunes, Sungyun Cho https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145280088-0XT2E5KT100G7HBREMJF/8.jpg Lab Events When we are not being an otherwise very cool lab, we are a very cool biker gang. (left to right) Tanya Schild, Andre Chavez, Michal Nagiec, John Blenis, Bethany Schaffer, Vivien Low, Joana Nunes September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145280853-WAQZ8KGTZY6321OOK4ZL/10.jpg Lab Events When all your projects aren’t going well… (left to right) Andre Chavez, Joana Nunes, John Blenis, Vivien Low, Tanya Schild https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145490908-0DEEAUJR5MUXZY86YB2D/11.jpg Lab Events A lab is a home. (left to right) John Blenis, Michal Nagiec, Tanya Schild, Vivien Low, Andre Chavez, Joana Nunes September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145491233-B8B6C0WH8FPFEJ2QA753/12.jpg Lab Events That time we lost John in the woods… September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145491489-SDSC0JC3I7EBJ3XQ6QLQ/13.jpg Lab Events Summer in September for our lab retreat (back row, left to right) Andreas Lamprakis, Kripa Ganesh, Bethany Schaffer, Andre Chavez, John Blenis (front row) Michal Nagiec, Vivien Low, Joana Nunes, Adam Rosenzweig, Sungyun Cho, Tasnia Islam September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145668080-TD68UPLMQIFY2U01WYEX/14.jpg Lab Events Taking a pit stop on a road trip for our lab retreat. (left to right) Vivien Low, Tasnia Islam, Adam Rosenzweig, Kripa Ganesh September 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145937216-7F2DAT96S0SCT1R41WZ8/15.jpg Lab Events Varying complexities of lab-built solar eclipse viewing contraptions (left to right) Adam Rosenzweig, Bethany Schaffer August 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146078006-7CEPJ9EHCJXGVU925R1J/17.jpg Lab Events Let’s talk about the White Elephant in the room. (left to right) Ana Gomes, Andre Chavez, Vivien Low, Parvez Rashid (labfriend) Tanya Schild, Bethany Schaffer, Christina Kam (labfriend) December 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525145937146-DMMKQM3I36LA5NS0CU7A/16.jpg Lab Events Watching the solar eclipse through several layers of burnt Western Blot film. Ingenius! (left to right) Joana Nunes, John Blenis August 2017 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146078121-I9SV4R6TRUI2AFTZJN9P/18.jpg Lab Events Getting a little artistic for Halloween. (left to right) Vivien Low, Joana Nunes, Julie Han, Tanya Schild and Ana Gomes October 2016 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146078539-5BNDEHTNTZKR6PBY9TTX/19.jpg Lab Events The traditional passing of the dissertation T-shirt as Gwen graduates! (left to right) Gwen Buel, Joana Nunes September 2016 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146196784-T5YR0URE0MRY4JRCSYYS/20.jpg Lab Events We are always proud to see our students graduate – congratulations Gwen! (left to right) Ana Gomes, Yihung Ou, John Blenis, Julie Han, Gwen Buel, Tanya Schild, Vivien Low, Bethany Schaffer, Sungyun Cho, Long He, Yasir Ibrahim September 2016 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146196850-I1MX95B9ATERUF7KVUT5/21.jpg Lab Events John and the postdocs at the Christmas Party (left to right) Gina Lee, Ana Gomes, Yasir Ibrahim, Michal Nagiec, Didem Ilter, John Blenis December 2015 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146197364-5WZUQJX70UKV1ERVKSS6/22.jpg Lab Events John and all his students at the Christmas Party (left to right) Tyler Thompson, Gwen Buel, Vivien Low, John Blenis, Tanya Schild, Joana Nunes December 2015 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1525146197536-0WUTIPTKK7TKYCKY6CUN/23.jpg Lab Events Getting in the spooky spirit for Halloween! (left to right) Didem Ilter, Ana Gomes, Gwen Buel, Gina Lee, Joana Nunes, Christina England, Julie Han October 2014 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1752001821802-6CY02LTJ2VQTJN7OX66G/IMG_8751.JPEG Lab Events https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1752001890721-9NQQ4HJ0FYPQGY2Q0VLJ/IMG_1312.jpg Lab Events https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1752001890576-OMPI9RX5ACWM6OX9MSI6/IMG_3391.jpg Lab Events https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1752001893145-1EIOZD8WP01AJ17S7N6E/IMG_3408.jpg Lab Events https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1752001893438-Y4484USZG3LJW4UM4KU1/IMG_3414.jpg Lab Events http://www.blenislab.org/home-2 daily 0.75 2020-04-22 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587579439670-KQSVXIF7O48UI8V3BC1L/WCMC14_Blenis+photo_14A9564.jpg Home (Copy) https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1524931991781-E5EA1NMISI03JZP42F9J/IMG_6666.jpg Home (Copy) - Welcome to the Blenis Lab The Blenis Laboratory investigates how cells sense and integrate cues to maintain cellular homeostasis. Particularly, we are interested in understanding how these mechanisms are hijacked by cancer cells to promote tumorigenesis and drug resistance. Utilizing state of the art technologies, we observe and manipulate these pathways in a variety of cell-based and mouse models of cancer. Additionally, our lab has made invaluable contributions to and continues to pioneer research in the study of lymphangioleiomyomatosis (LAM), an orphan disease affecting women of childbearing age, and has established a unique mouse model for this disease. The Blenis Laboratory is a part of the Meyer Cancer Center at Weill Cornell Medicine, a newly established cancer center in the heart of NYC. Dr. Blenis heads the Department of Pharmacology at Weill Cornell Medicine and is affiliated with the Tri-Institutional training programs (centered among three premier New York Institutions: Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and the Rockefeller University.) https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1586242696177-9M3H2S8R97GTMDUUEWGK/Mutvei%2B2020.jpg Home (Copy) https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1580193928249-YGWMMG1WA8M07UB7DU16/gomes%2Bet%2Bal..jpg Home (Copy) https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1674595111433-VYYUGNTQYC9TFNF5VGOM/long%252Bet%252Bal_pnas.jpg Home (Copy) https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1580193978549-7I5CJDF3N0EGVMOFMSJS/long%2Bet%2Bal..jpg Home (Copy) http://www.blenislab.org/nikolaos-koundouros daily 0.75 2023-07-25 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/26f8fe0f-738a-4b90-8194-435d9dc5b963/NK_photo.jpg Nikolaos Koundouros https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/26f8fe0f-738a-4b90-8194-435d9dc5b963/NK_photo.jpg Nikolaos Koundouros http://www.blenislab.org/aristotle-lau daily 0.75 2023-07-25 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/6cf383cb-b17d-4616-aba2-6a5fb4519215/DSC_1588.JPG Aristotle Lau https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/6cf383cb-b17d-4616-aba2-6a5fb4519215/DSC_1588.JPG Aristotle Lau http://www.blenislab.org/evan-noch daily 0.75 2023-01-17 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/1587085433653-734OJW0FRC4AS60EKGID/Smiley.jpg Evan Noch http://www.blenislab.org/moniquetta-shafer daily 0.75 2023-01-26 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/0f988d82-9fdc-40fc-b5e0-f45b5b20bef9/image.png Moniquetta Shafer https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/0f988d82-9fdc-40fc-b5e0-f45b5b20bef9/image.png Moniquetta Shafer http://www.blenislab.org/guillermo-burgos-barraga daily 0.75 2023-01-26 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/27e4b47c-9645-4f01-a41f-eda9cad0b3cd/Lab+picture_Guillermo.jpg Lab memGuillermo Burgos Barraga https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/27e4b47c-9645-4f01-a41f-eda9cad0b3cd/Lab+picture_Guillermo.jpg Lab memGuillermo Burgos Barraga http://www.blenislab.org/bobak-parang daily 0.75 2023-07-25 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/353356ee-619b-4428-803e-8342a02e4635/bop9014.jpg Bobak Parang https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/353356ee-619b-4428-803e-8342a02e4635/bop9014.jpg Bobak Parang http://www.blenislab.org/new-page-1 daily 0.75 2025-02-10 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/94d832fb-4070-43d4-888a-175e96013a79/Central+park+headshot+%281%29.jpg New Page - Bethany Schaffer Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/08a944a0-9039-4cfa-a38e-8982fb529982/bop9014.jpg New Page - Bobak Parang Assistant Professor of Medicine Division of Hematology and Oncology https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/9acd8ed1-2fdf-4017-9189-f6e32ce22a71/michal.jpg New Page - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/fb455754-775d-4071-a51d-9e8e56d6fe0b/John%2BBlenis.jpg New Page - Principal Investigator John Blenis, Ph.D. Anna-Maria and Stephen Kellen Professor in Cancer Research Associate Director of Basic Science, The Sandra and Edward Meyer Cancer Center Professor of Pharmacology Director, Pharmacology Ph.D. Program job2064@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/94d832fb-4070-43d4-888a-175e96013a79/Central+park+headshot+%281%29.jpg New Page - Bethany Schaffer, Ph.D. Research Associate bes2032@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/08a944a0-9039-4cfa-a38e-8982fb529982/bop9014.jpg New Page - Bobak Parang, MD, Ph.D. Assistant Professor of Medicine, Division of Hematology and Oncology bop9014@med.cornell.edu As a member of the Weill Cornell Medicine faculty, Dr. Parang is a physician-scientist whose clinical and scientific research interests are focused on lung cancer drug resistance and metastases. In particular, he is working on overcoming drug resistance in EGFR-driven lung cancers. He received a K08 Career Development award in 2024 to continue his work on lung cancer. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/68120b6c-2ae6-4b1b-9095-99cf52c38a54/DSC07988.jpg New Page - Guillermo Burgos Barragan, Ph.D. Post-Doctoral Associate gbb4001@med.cornell.edu Dr. Barragan’s research focuses on understanding and exploiting the connection between metabolism and DNA stability in cancer. He is developing a novel therapeutic strategy that uses high doses of vitamins to selectively eliminate cancer cells by generating metabolic genotoxins. Additionally, Guillermo is investigating how vitamin deficiencies contribute to cancer development. In 2024, he was awarded the Idea Development Award from the Department of Defense Lung Cancer Research Program and an R03 grant from the National Cancer Institute to support his work. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/989beecc-7c0e-4338-9429-d60c2abdd541/DSC08047.jpg New Page - Jacob Cecil, Ph.D. Post-Doctoral Associate jhc4005@med.cornell.edu Dr. Cecil's research focuses on the fundamental processes regulating cell growth through mitogenic signaling, specifically via the mTORC1 pathway. In particular, his project seeks to explore new roles for kinase signaling in the process of ribosome biogenesis. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/bbbe4577-deb2-48a9-a41f-8c932160f33b/DSC07883.jpg New Page - Long He, Ph.D. Instructor loh2007@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/65111a2b-8908-43ae-a3e1-181b0e8618d3/DSC08055.jpg New Page - Nikos Koundouros, Ph.D. Post-Doctoral Associate nik4009@med.cornell.edu As a Charles H. Revson Fellow in the Blenis Lab, Dr. Koundouros work focuses on delineating the mechanisms through which breast cancer cells sense and utilize dietary essential fatty acids to fuel their growth and proliferation. The ultimate goal of this work is to develop personalized therapeutic strategies that combine nutritional and pharmacological interventions to exploit these genetic and metabolic interactions. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/e1b92001-8d22-4866-986c-24b8cf46c6ce/Image-23.jpg New Page - Shuchen Liu Post-Doctoral Associate shl2044@med.cornell.edu Dr. Liu is a postdoctoral researcher who focuses on steroidogenesis during cancer metastasis, with a particular interest on breast cancer. Her research aims to investigate glucocorticoids regulation, androgenic and estrogenic the conversion in cells undergoing epithelial-to-mesenchymal transition (EMT), and to uncover the underlying mechanisms and downstream pathways involved. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/9acd8ed1-2fdf-4017-9189-f6e32ce22a71/michal.jpg New Page - Michal Nagiec, Ph.D. Instructor min2015@med.cornell.edu Dr. Nagiec is a cell biologist with training in pharmacology that is interested in the fundamental questions of how cells process information and produce appropriate responses. He is particularly interested in how metastatic cancer cells balance proliferation with the ability to migrate and how these cells adapt to stresses associated with tumor spread. The goal of his research is to identify and exploit vulnerabilities in processes unique to metastatic cells for therapeutic benefit. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/724bab1e-0156-44bb-8598-4fa4828ec590/DSC08024.jpg New Page - Sungyun Cho, Ph.D. Post-Doctoral Associate sch2004@med.cornell.edu Dr. Cho is a postdoctoral researcher focused on understanding how cellular signaling regulates RNA biogenesis, including processes such as RNA splicing and epitranscriptomic modification. His work specifically investigates the roles of mTORC1 and SRPK2 signaling pathways, which are highly active in cancers, and how they influence RNA splicing to mediate resistance to immuno- and chemotherapy in cancer treatment. https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/f18fc84a-f8f5-4d56-81c6-82f8456684c9/DSC07927.jpg New Page - Zhongchi Li, Ph.D. Instructor zhl4003@med.cornell.edu With comprehensive training in aging biology and physiology, Dr. Li is focused on understanding how age-related metabolic dysfunction contributes to cancer progression. In particular, his research explores how propionate metabolism influences both tumor cells and the tumor microenvironment, driving therapy resistance and metastasis. Dr. Li has been recognized for his work with the Glenn Foundation Postdoctoral Fellowship and a K99/R00 Career Development Award from the NIA. http://www.blenislab.org/graduatestudents daily 0.75 2025-02-10 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/fb455754-775d-4071-a51d-9e8e56d6fe0b/John%2BBlenis.jpg Graduate Students - Principal Investigator John Blenis, Ph.D. Anna-Maria and Stephen Kellen Professor in Cancer Research Associate Director of Basic Science, The Sandra and Edward Meyer Cancer Center Professor of Pharmacology Director, Pharmacology Ph.D. Program job2064@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/c5e9d0b7-3ce6-42d6-b2f1-10638b78013f/aris.jpg Graduate Students Aristotle Lau Cheng Ph.D. Student in Chemical Biology acl4001@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/2fc15c74-202c-4ae7-9669-f4ff7956acb6/Jenn.jpg Graduate Students - Jennifer Endress Ph.D. Student in Biochemistry and Structural Biology jee4001@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/f185932f-678d-49c3-87d8-f173375bee3e/Moni.jpg Graduate Students - Moniquetta Shafer M. Ed., PMP Ph.D. Student in Pharmacology mos4011@med.cornell.edu Moniquetta works to understand how cancer cells alter metabolic pathways to enable metastatic progression. Specifically, she is working on understanding how abnormal accumulation of propionate metabolism intermediates may support cancer cell ability to activate cell migration and chemoresistance. http://www.blenislab.org/researchtechnicians daily 0.75 2025-02-10 https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/fb455754-775d-4071-a51d-9e8e56d6fe0b/John%2BBlenis.jpg Research Technicians - Principal Investigator John Blenis, Ph.D. Anna-Maria and Stephen Kellen Professor in Cancer Research Associate Director of Basic Science, The Sandra and Edward Meyer Cancer Center Professor of Pharmacology Director, Pharmacology Ph.D. Program job2064@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/088f1f0e-6fb3-42e4-8bb5-ba5edf740c34/JB_RabiaKhanHeadshot.jpg Research Technicians Rabia Khan Research Technician II rkh4005@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/9819b64c-86b9-41e5-92e6-926cab888aa0/nayah.jpg Research Technicians - Nayah Bullen Research Technician II nab4014@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/027a39e6-2e22-4607-8afa-da9ebbc11d2b/DSC07953.JPG Research Technicians - Olivia Kester Research Technician I olk4005@med.cornell.edu https://images.squarespace-cdn.com/content/v1/5410e984e4b06256da3c6ca1/6e6c38f7-4528-43f9-9e87-4fdf69fecbf1/daniel.jpg Research Technicians Junghwan (Daniel) Lee Research Technician I jul4020@med.cornell.edu