Recent Publications
Li Z, Low V, Luga V, Sun J, Earlie E, Parang B, Shobana Ganesh K, Cho S, Endress J, Schild T, Hu M, Lyden D, Jin W, Guo C, Dephoure N, Cantley LC, Laughney AM, Blenis J. Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nat Commun. 2022 Oct 20;13(1):6239. doi: 10.1038/s41467-022-33862-0. PMID: 36266345; PMCID: PMC9584945.
He L, Endress J, Cho S, Li Z, Zheng Y, Asara JM, Blenis J. Suppression of nuclear GSK3 signaling promotes serine/one-carbon metabolism and confers metabolic vulnerability in lung cancer cells. Sci Adv. 2022 May 20;8(20):eabm8786. doi: 10.1126/sciadv.abm8786. Epub 2022 May 20. PMID: 35594343; PMCID: PMC9122323.
Buel GR, Dang HQ, Asara JM, Blenis J, Mutvei AP. Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1. J Biol Chem. 2022 Jun;298(6):102030. doi: 10.1016/j.jbc.2022.102030. Epub 2022 May 13. PMID: 35577075; PMCID: PMC9194872.
Koundouros N, Blenis J. Targeting mTOR in the Context of Diet and Whole-body Metabolism. Endocrinology. 2022 Jun 1;163(6):bqac041. doi: 10.1210/endocr/bqac041. PMID: 35366325; PMCID: PMC9391686.
Gomes AP, Ilter D, Low V, Drapela S, Schild T, Mullarky E, Han J, Elia I, Broekaert D, Rosenzweig A, Nagiec M, Nunes JB, Schaffer BE, Mutvei AP, Asara JM, Cantley LC, Fendt SM, Blenis J. Altered propionate metabolism contributes to tumour progression and aggressiveness. Nat Metab. 2022 Apr;4(4):435-443. doi: 10.1038/s42255-022-00553-5. Epub 2022 Mar 31. PMID: 35361954; PMCID: PMC9050834.
Campbell S, Mesaros C, Izzo L, Affronti H, Noji M, Schaffer BE, Tsang T, Sun K, Trefely S, Kruijning S, Blenis J, Blair IA, Wellen KE. Glutamine deprivation triggers NAGK-dependent hexosamine salvage. Elife. 2021 Nov 30;10:e62644. doi: 10.7554/eLife.62644. PMID: 34844667; PMCID: PMC8631944.
Schild T, McReynolds MR, Shea C, Low V, Schaffer BE, Asara JM, Piskounova E, Dephoure N, Rabinowitz JD, Gomes AP, Blenis J. NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma. Cell Rep. 2021 Jun 15;35(11):109238. doi: 10.1016/j.celrep.2021.109238. PMID: 34133937.
Cho S, Lee G, Pickering BF, Jang C, Park JH, He L, Mathur L, Kim SS, Jung S, Tang HW, Monette S, Rabinowitz JD, Perrimon N, Jaffrey SR, Blenis J. mTORC1 promotes cell growth via m6A-dependent mRNA degradation. Mol Cell. 2021 May 20;81(10):2064-2075.e8. doi: 10.1016/j.molcel.2021.03.010. Epub 2021 Mar 22. PMID: 33756105; PMCID: PMC8356906.
Tang HW, Weng JH, Lee WX, Hu Y, Gu L, Cho S, Lee G, Binari R, Li C, Cheng ME, Kim AR, Xu J, Shen Z, Xu C, Asara JM, Blenis J, Perrimon N. mTORC1-chaperonin CCT signaling regulates m6A RNA methylation to suppress autophagy. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2021945118. doi: 10.1073/pnas.2021945118. PMID: 33649236; PMCID: PMC7958400.
Gomes AP, Ilter D, Low V, Endress JE, Fernández-García J, Rosenzweig A, Schild T, Broekaert D, Ahmed A, Planque M, Elia I, Han J, Kinzig C, Mullarky E, Mutvei AP, Asara J, de Cabo R, Cantley LC, Dephoure N, Fendt SM, Blenis J. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020 Sep;585(7824):283-287. doi: 10.1038/s41586-020-2630-0. Epub 2020 Aug 19. PMID: 32814897; PMCID: PMC7785256.
Park JH, Lee G, Blenis J. Structural Insights into the Activation of mTORC1 on the Lysosomal Surface. Trends Biochem Sci. 2020 May;45(5):367-369. doi:10.1016/j.tibs.2020.02.004. Epub 2020 Feb 27. PubMed PMID: 32311329.
Mutvei AP, Nagiec MJ, Hamann JC, Kim SG, Vincent CT, Blenis J. Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability. Nat Commun. 2020;11(1):1416. Published 2020 Mar 17. doi:10.1038/s41467-020-15156-5
Ilter D, Blenis J, Gomes AP. Histone H3 variants at the root of metastasis. Mol Cell Oncol. 2020;7(2):1684128. Published 2020 Jan 10. doi:10.1080/23723556.2019.1684128
Gomes AP*, Ilter D*, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, Shin S, Yoon SO, Dephoure N, Massagué J, Melnick AM, Cantley LC, Tyler JK, Blenis J. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019 Oct 14;36(4):402-417.e13. doi: 10.1016/j.ccell.2019.08.006. Epub 2019 Sep 26. PubMed PMID: 31564638; PubMed Central PMCID: PMC6801101.
He L, Fei DL, Nagiec MJ, Mutvei AP, Lamprakis A, Kim BY, Blenis J. Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin. Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19523-19529. doi: 10.1073/pnas.1902397116. Epub 2019 Sep 6. PubMed PMID: 31492813; PubMed Central PMCID: PMC6765302.
Samson SC, Elliott A, Mueller BD, Kim Y, Carney KR, Bergman JP, Blenis J, Mendoza MC. p90 ribosomal S6 kinase (RSK) phosphorylates myosin phosphatase and thereby controls edge dynamics during cell migration. J Biol Chem. 2019 Jul 12;294(28):10846-10862. doi: 10.1074/jbc.RA119.007431. Epub 2019 May 28. PubMed PMID: 31138649; PubMed Central PMCID: PMC6635457.
Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2967-2976. doi: 10.1073/pnas.1811923116. Epub 2019 Feb 6. PubMed PMID: 30728292; PubMed Central PMCID: PMC6386703.
Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC. Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 2018 Nov 29;175(6):1546-1560.e17. doi: 10.1016/j.cell.2018.09.041. PubMed PMID: 30500537; PubMed Central PMCID: PMC6568313.
Krishnamoorthy GP, Davidson NR, Leach SD, Zhao Z, Lowe SW, Lee G, Landa I, Nagarajah J, Saqcena M, Singh K, Wendel HG, Dogan S, Tamarapu PP, Blenis J, Ghossein RA, Knauf JA, Rätsch G, Fagin JA. EIF1AX and RAS Mutations Cooperate to Drive Thyroid Tumorigenesis through ATF4 and c-MYC. Cancer Discov. 2019 Feb;9(2):264-281. doi: 10.1158/2159-8290.CD-18-0606. Epub 2018 Oct 10. PubMed PMID: 30305285; PubMed Central PMCID: PMC6373451.
Rosenzweig A, Blenis J, Gomes AP. Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism? Front Cell Dev Biol. 2018 Aug 15;6:90. doi: 10.3389/fcell.2018.00090. eCollection 2018. Review. PubMed PMID: 30159313; PubMed Central PMCID: PMC6103474.
He L, Gomes AP, Wang X, Yoon SO, Lee G, Nagiec MJ, Cho S, Chavez A, Islam T, Yu Y, Asara JM, Kim BY, Blenis J. mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation. Mol Cell. 2018 Jun 7;70(5):949-960.e4. doi: 10.1016/j.molcel.2018.04.024. Epub 2018 May 31. PubMed PMID: 29861159; PubMed Central PMCID: PMC6591025.
Maik-Rachline G, Zehorai E, Hanoch T, Blenis J, Seger R. The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer. Sci Signal. 2018 Apr 10;11(525). pii: eaao3428. doi: 10.1126/scisignal.aao3428. PubMed PMID: 29636389.
Schild T, Low V, Blenis J, Gomes AP. Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization. Cancer Cell. 2018 Mar 12;33(3):347-354. Review. PubMed PMID: 29533780.
Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat Cell Biol. 2018 Mar; 20(3):332-343. PMID: 29459780.
Oldrini B, Hsieh WY, Erdjument-Bromage H, Codega P, Carro MS, Curiel-GarcíaA, Campos C, Pourmaleki M, Grommes C, Vivanco I, Rohle D, Bielski CM, Taylor BS, Hollmann TJ, Rosenblum M, Tempst P, Blenis J, Squatrito M, Mellinghoff IK. EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. Nat Commun. 2017 Dec 11;8(1):2035. PMID: 29229958
Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. 2017 Dec 14;171(7):1545-1558.e18. PMID: 29153836.
Blenis J. TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease. Cell. 2017 Sep 21;171(1):10-13. doi: 10.1016/j.cell.2017.08.019. PMID: 28888322.
Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Mol Cell. 2017 Aug 3;67(3):512-527.e4. PMID: 28757207
Gomes AP, Schild T, Blenis J. Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer. Dev Cell. 2017 Jul 24;42(2):112-114. PMID: 28742999