Selected Publications

Shin S, Buel GR, Wolgamott L, Plas DR, Asara JM, Blenis J, Yoon SO. ERK2 Mediates                                                                         Metabolic Stress Response to Regulate Cell Fate. Mol Cell. 2015 Aug 6;59(3):382-98.                                                                         [PMID: 26190261]

                                                                                                                                                                                                                  Gomes AP, Blenis J. A nexus for cellular homeostasis: the interplay between metabolic                                                                              and signal transduction pathways. Curr Opin Biotechnol. 2015 Jan 3;34C:110-117. Review.                                                                  [PMID: 25562138]


Li J, Csibi A, Yang S, Hoffman GR, Li C, Zhang E, Yu JJ, Blenis J. Synthetic
lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor
cells.
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E21-9. [PMID: 25524627]

                                                                                                                                                                                                                     Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ,
Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR.
FLCN, a novel autophagy component, interacts with GABARAP and is regulated by
ULK1 phosphorylation.
Autophagy. 2014 Oct 1;10(10):1749-60. [PMID: 25126726]


Csibi A*, Lee G*, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis
J. The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the
eIF4B-Dependent Control of c-Myc Translation.
Curr Biol. 2014 Sep 9. pii:
S0960-9822(14)00985-3. (*co-first autors)  [PMID: 25220053] [PDF]


Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V,
Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP. Phosphoproteomic
analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively
regulated by 14-3-3.
Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27.
[PMID: 25002506] [PDF]


Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu
Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F. Grb10 promotes lipolysis and
thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.
Cell
Metab. 2014 Jun 3;19(6):967-80.  [PMID: 24746805] [PDF]


Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna
RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. Quantitative phosphoproteomic
analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in
breast cancer stem cells.
Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2182-90.
[PMID: 24782546] [PDF]


Sun Y, Gu X, Zhang E, Park MA, Pereira AM, Wang S, Morrison T, Li C, Blenis J,
Gerbaudo VH, Henske EP, Yu JJ. Estradiol promotes pentose phosphate pathway
addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.

Cell Death Dis. 2014 May 15;5:e1231.  [PMID:24832603] [PDF]


Li J, Kim SG, Blenis J. Rapamycin: one drug, many effects. Cell Metab. 2014
Mar 4;19(3):373-9.
[PMID:24508508] [PDF]


Lee G, Blenis J. Akt-ivation of RNA splicing. Mol Cell. 2014 Feb 20;53(4):519-20.
[PMID: 24560271] [PDF]


Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J,
Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, Israel E, Xu KF, Henske
EP, Blenis J, Levy BD, Kwiatkowski D, Yu JJ. Estradiol and mTORC2 cooperate to
enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.

J Exp Med. 2014 Jan 13;211(1):15-28.
[PMID: 24395886] [ ]


Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B,
Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD,
Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and
inhibits downstream Akt signalling to suppress tumorigenesis.
Nat Cell Biol. 2013
Nov;15(11):1340-50.
[PMID:24161930] [ ]


Gu X, Yu JJ, Ilter D, Blenis N, Henske EP, Blenis J. Integration of mTOR and
estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.
Proc Natl Acad
Sci U S A. 2013 Sep 10;110(37):14960-5.
[PMID: 23983265] [ ]


Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR,
Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L,
Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G. Metformin
decreases glucose oxidation and increases the dependency of prostate cancer cells
on reductive glutamine metabolism.
Cancer Res. 2013 Jul 15;73(14):4429-38.
[PMID: 23687346]


Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J. AKT facilitates EGFR
trafficking and degradation by phosphorylating and activating PIKfyve.
Sci
Signal. 2013 Jun 11;6(279):ra45.
[PMID: 23757022]


Kim SG, Buel GR, Blenis J. Nutrient regulation of the mTOR complex 1
signaling pathway.
Mol Cells. 2013 Jun;35(6):463-73.
[PMID: 23694989]


Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM,
Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC,
Stephanopoulos G, Yu J, Blenis J. The mTORC1 pathway stimulates glutamine
metabolism and cell proliferation by repressing SIRT4.
Cell. 2013 May
9;153(4):840-54.
[PMID: 23663782]


Buel GR, Kim SG, Blenis J. mTORC1 signaling aids in CADalyzing pyrimidine
biosynthesis.
Cell Metab. 2013 May 7;17(5):633-5.
[PMID: 23663734]


Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X,
Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J,
Clish CB, Kimmelman A, Deng CX, Haigis MC. SIRT4 has tumor-suppressive activity
and regulates the cellular metabolic response to DNA damage by inhibiting
mitochondrial glutamine metabolism.
Cancer Cell. 2013 Apr 15;23(4):450-63.
[PMID: 23562301]


Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson
RL, Cantley LC, Choo AY, Blenis J. Metabolic stress controls mTORC1 lysosomal
localization and dimerization by regulating the TTT-RUVBL1/2 complex.
Mol Cell.
2013 Jan 10;49(1):172-85.
[PMID: 23142078]


Csibi A, Blenis J. Hippo-YAP and mTOR pathways collaborate to regulate organ
size.
Nat Cell Biol. 2012 Dec;14(12):1244-5.
[PMID:23196842]


Anjum R, Pae E, Blenis J, Ballif BA. TPCK inhibits AGC kinases by direct
activation loop adduction at phenylalanine-directed cysteine residues.
FEBS Lett.
2012 Sep 21;586(19):3471-6. [PMID: 22967899]


Zhang W, Mendoza MC, Pei X, Ilter D, Mahoney SJ, Zhang Y, Ma D, Blenis J,
Wang Y. Down-regulation of CMTM8 induces epithelial-to-mesenchymal
transition-like changes via c-MET/extracellular signal-regulated kinase (ERK)
signaling.
J Biol Chem. 2012 Apr 6;287(15):11850-8. PMID: 22337876


Shin S, Wolgamott L, Yu Y, Blenis J, Yoon SO. Glycogen synthase kinase
(GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell
proliferation.
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):E1204-13. PMID: 22065737


Csibi A, Blenis J. Appetite for destruction: the inhibition of glycolysis as
a therapy for tuberous sclerosis complex-related tumors.
BMC Biol. 2011 Oct
21;9:69. PMID: 22018140


Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR,
Cantley LC, Gygi SP, Blenis J. Phosphoproteomic analysis identifies Grb10 as an
mTORC1 substrate that negatively regulates insulin signaling.
Science. 2011 Jun
10;332(6035):1322-6. PMID: 21659605


Mendoza MC, Er EE, Blenis J. The Ras-ERK and PI3K-mTOR pathways: cross-talk
and compensation.
Trends Biochem Sci. 2011 Jun;36(6):320-8. PMID: 21531565


Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J.
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory
complex.
Mol Cell. 2011 Mar 18;41(6):661-71. PMID: 21419341


Kim SG, Choo AY, Blenis J. ATM: Promoter of metabolic "cost" reduction and
"savings" usage during hypoxia through mTORC1 regulation.
Mol Cell. 2010 Nov
24;40(4):501-2. PMID: 21095578.


Shin S, Blenis J. ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal
transition.
Cell Cycle. 2010 Jul 1;9(13):2483-4. PMID: 20543576.


Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu
J, Blenis J, Xavier RJ, Yuan J. A genome-wide siRNA screen reveals multiple
mTORC1 independent signaling pathways regulating autophagy under normal
nutritional conditions.
Dev Cell. 2010 Jun 15;18(6):1041-52. PMID: 20627085


Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC,
Blenis J. Glucose addiction of TSC null cells is caused by failed
mTORC1-dependent balancing of metabolic demand with supply.
Mol Cell. 2010 May
28;38(4):487-99. PMID: 20513425


Shin S, Dimitri CA, Yoon SO, Dowdle W, Blenis J. ERK2 but not ERK1 induces
epithelial-to-mesenchymal transformation via DEF motif-dependent signaling
events.
Mol Cell. 2010 Apr 9;38(1):114-27. PMID: 20385094


Hoffman GR, Moerke NJ, Hsia M, Shamu CE, Blenis J. A high-throughput,
cell-based screening method for siRNA and small molecule inhibitors of mTORC1
signaling using the In Cell Western technique.
Assay Drug Dev Technol. 2010
Apr;8(2):186-99. PMID: 20085456


Mendoza MC, Er EE, Blenis J. ERK-MAP Kinase signaling in the cytoplasm.
Methods Mol Biol. 2010;661:185-203. PMID: 20811984.


Abe Y, Yoon SO, Kubota K, Mendoza MC, Gygi SP, Blenis J. p90 ribosomal S6
kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic
chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.
J
Biol Chem. 2009 May 29;284(22):14939-48. PMID: 19332537


Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control.
Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. PMID: 19339977.


Choo AY, Blenis J. Not all substrates are treated equally: implications for
mTOR, rapamycin-resistance and cancer therapy. Cell Cycle. 2009 Feb
15;8(4):567-72. PMID: 19197153.


Rahimi RA, Andrianifahanana M, Wilkes MC, Edens M, Kottom TJ, Blenis J, Leof
EB. Distinct roles for mammalian target of rapamycin complexes in the fibroblast
response to transforming growth factor-beta. Cancer Res. 2009 Jan 1;69(1):84-93.
PMID: 19117990


Mahoney SJ, Dempsey JM, Blenis J. Cell signaling in protein synthesis
ribosome biogenesis and translation initiation and elongation. Prog Mol Biol
Transl Sci. 2009;90:53-107. PMID: 20374739.


Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. Rapamycin differentially
inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA
translation. Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17414-9.
PMID: 18955708


Anjum R, Blenis J. The RSK family of kinases: emerging roles in cellular
signalling. Nat Rev Mol Cell Biol. 2008 Oct;9(10):747-58. PMID: 18813292.


Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates
Myc-mediated transcription by phosphorylating and promoting the degradation of
Mad1. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6584-9. PMID: 18451027


Carriere A, Ray H, Blenis J, Roux PP. The RSK factors of activating the
Ras/MAPK signaling cascade. Front Biosci. 2008 May 1;13:4258-75.
PMID: 18508509.


Ma XM, Yoon SO, Richardson CJ, Jülich K, Blenis J. SKAR links pre-mRNA
splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.
Cell. 2008 Apr 18;133(2):303-13. PMID:18423201.


Yoon SO, Shin S, Liu Y, Ballif BA, Woo MS, Gygi SP, Blenis J. Ran-binding
protein 3 phosphorylation links the Ras and PI3-kinase pathways to
nucleocytoplasmic transport. Mol Cell. 2008 Feb 15;29(3):362-75. PMID: 18280241


Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N,
Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6
phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem.
2007 May 11;282(19):14056-64. PMID: 17360704


Mendoza MC, Blenis J. PHLPPing it off: phosphatases get in the Akt. Mol Cell.
2007 Mar 23;25(6):798-800. PMID: 17386258.


Choo AY, Roux PP, Blenis J. Mind the GAP: Wnt steps onto the mTORC1 train.
Cell. 2006 Sep 8;126(5):834-6. PMID: 16959561.


Kim M, Lee JH, Koh H, Lee SY, Jang C, Chung CJ, Sung JH, Blenis J, Chung J.
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO
J. 2006 Jul 12;25(13):3056-67. PMID: 16763554


Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW,
Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B
to control its phosphorylation and activity. EMBO J. 2006 Jun 21;25(12):2781-91.
PMID: 16763566


Murphy LO, Blenis J. MAPK signal specificity: the right place at the right
time. Trends Biochem Sci. 2006 May;31(5):268-75. PMID: 16603362.


Choo AY, Blenis J. TORgeting oncogene addiction for cancer therapy. Cancer
Cell. 2006 Feb;9(2):77-9. PMID: 16473275.


Holz MK, Ballif BA, Gygi SP, Blenis J. mTOR and S6K1 mediate assembly of the
translation preinitiation complex through dynamic protein interchange and ordered
phosphorylation events. Cell. 2005 Nov 18;123(4):569-80. PMID: 16286006.


Anjum R, Roux PP, Ballif BA, Gygi SP, Blenis J. The tumor suppressor DAP
kinase is a target of RSK-mediated survival signaling. Curr Biol. 2005 Oct
11;15(19):1762-7. PMID: 16213824.


Dimitri CA, Dowdle W, MacKeigan JP, Blenis J, Murphy LO. Spatially separate
docking sites on ERK2 regulate distinct signaling events in vivo. Curr Biol. 2005
Jul 26;15(14):1319-24. PMID: 16051177.


Holz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target
of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem. 2005 Jul
15;280(28):26089-93.PMID: 15905173.


Mackeigan JP, Murphy LO, Dimitri CA, Blenis J. Graded mitogen-activated
protein kinase activity precedes switch-like c-Fos induction in mammalian cells.
Mol Cell Biol. 2005 Jun;25(11):4676-82. PMID: 15899869


MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases
and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat
Cell Biol. 2005 Jun;7(6):591-600. PMID: 15864305.


Schalm SS, Tee AR, Blenis J. Characterization of a conserved C-terminal motif
(RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of
rapamycin-dependent regulation. J Biol Chem. 2005 Mar 25;280(12):11101-6.PMID: 15659381.


Tee AR, Blenis J. mTOR, translational control and human disease. Semin Cell
Dev Biol. 2005 Feb;16(1):29-37. PMID: 15659337.


Ballif BA, Roux PP, Gerber SA, MacKeigan JP, Blenis J, Gygi SP. Quantitative
phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette
and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S
A. 2005 Jan 18;102(3):667-72. PMID: 15647351


Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J. Tumor-promoting phorbol
esters and activated Ras inactivate the tuberous sclerosis tumor suppressor
complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A. 2004 Sep
14;101(37):13489-94. PMID: 15342917


Richardson CJ, Bröenstrup M, Fingar DC, Jülich K, Ballif BA, Gygi S, Blenis
J. SKAR is a specific target of S6 kinase 1 in cell growth control. Curr Biol.
2004 Sep 7;14(17):1540-9. PMID: 15341740.


Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of
protein kinases with diverse biological functions. Microbiol Mol Biol Rev. 2004
Jun;68(2):320-44. PMID: 15187187


Tee AR, Tee JA, Blenis J. Characterizing the interaction of the mammalian
eIF4E-related protein 4EHP with 4E-BP1. FEBS Lett. 2004 Apr 23;564(1-2):58-62.
PMID: 15094042.


Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and
growth factor signals and coordinator of cell growth and cell cycle progression.
Oncogene. 2004 Apr 19;23(18):3151-71. PMID: 15094765.


Woo MS, Ohta Y, Rabinovitz I, Stossel TP, Blenis J. Ribosomal S6 kinase (RSK)
regulates phosphorylation of filamin A on an important regulatory site. Mol Cell
Biol. 2004 Apr;24(7):3025-35. PMID: 15024089


Richardson CJ, Schalm SS, Blenis J. PI3-kinase and TOR: PIKTORing cell
growth. Semin Cell Dev Biol. 2004 Apr;15(2):147-59. PMID:
15209374.


Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls
cell cycle progression through its cell growth effectors S6K1 and
4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol. 2004
Jan;24(1):200-16. PMID: 14673156


Murphy LO, MacKeigan JP, Blenis J. A network of immediate early gene products
propagates subtle differences in mitogen-activated protein kinase signal
amplitude and duration. Mol Cell Biol. 2004 Jan;24(1):144-53. PMID:
14673150


Tee AR, Anjum R, Blenis J. Inactivation of the tuberous sclerosis complex-1
and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and
-independent phosphorylation of tuberin. J Biol Chem. 2003 Sep
26;278(39):37288-96.PMID: 12867426.


Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J. Tuberous sclerosis complex
gene products, Tuberin and Hamartin, control mTOR signaling by acting as a
GTPase-activating protein complex toward Rheb. Curr Biol. 2003 Aug
5;13(15):1259-68. PMID: 12906785.


Roux PP, Richards SA, Blenis J. Phosphorylation of p90 ribosomal S6 kinase
(RSK) regulates extracellular signal-regulated kinase docking and RSK activity.
Mol Cell Biol. 2003 Jul;23(14):4796-804. PMID: 12832467


Schalm SS, Fingar DC, Sabatini DM, Blenis J. TOS motif-mediated raptor
binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol. 2003
May 13;13(10):797-806. PMID: 12747827.


Romanelli A, Dreisbach VC, Blenis J. Characterization of phosphatidylinositol
3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70
S6 kinase 1. J Biol Chem. 2002 Oct 25;277(43):40281-9.
PMID: 12183455.


Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous
sclerosis complex-1 and -2 gene products function together to inhibit mammalian
target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S
A. 2002 Oct 15;99(21):13571-6. PMID: 12271141


Murphy LO, Smith S, Chen RH, Fingar DC, Blenis J. Molecular interpretation of
ERK signal duration by immediate early gene products. Nat Cell Biol. 2002
Aug;4(8):556-64. PMID: 12134156.


Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the
tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of
the phosphoinositide 3-kinase/akt pathway. Mol Cell. 2002 Jul;10(1):151-62.
PMID: 12150915.


Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is
controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev.
2002 Jun 15;16(12):1472-87. PMID: 12080086


Schalm SS, Blenis J. Identification of a conserved motif required for mTOR
signaling. Curr Biol. 2002 Apr 16;12(8):632-9. PMID: 11967149.


Martin KA, Blenis J. Coordinate regulation of translation by the PI 3-kinase
and mTOR pathways. Adv Cancer Res. 2002;86:1-39. PMID: 12374276.


Richards SA, Dreisbach VC, Murphy LO, Blenis J. Characterization of
regulatory events associated with membrane targeting of p90 ribosomal S6 kinase
1. Mol Cell Biol. 2001 Nov;21(21):7470-80. PMID: 11585927


Ballif BA, Blenis J. Molecular mechanisms mediating mammalian
mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.
Cell Growth Differ. 2001 Aug;12(8):397-408.PMID: 11504705.


Ballif BA, Shimamura A, Pae E, Blenis J. Disruption of
3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic
and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone. J
Biol Chem. 2001 Apr 13;276(15):12466-75. PMID: 11278584.


Martin KA, Schalm SS, Romanelli A, Keon KL, Blenis J. Ribosomal S6 kinase 2
inhibition by a potent C-terminal repressor domain is relieved by
mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated
phosphorylation. J Biol Chem. 2001 Mar 16;276(11):7892-8.
PMID: 11108720.


Martin KA, Schalm SS, Richardson C, Romanelli A, Keon KL, Blenis J.
Regulation of ribosomal S6 kinase 2 by effectors of the phosphoinositide 3-kinase
pathway. J Biol Chem. 2001 Mar 16;276(11):7884-91. PMID:11108711.


Shimamura A, Ballif BA, Richards SA, Blenis J. Rsk1 mediates a MEK-MAP kinase
cell survival signal. Curr Biol. 2000 Feb 10;10(3):127-35. PMID: 10679322.


Juo P, Woo MS, Kuo CJ, Signorelli P, Biemann HP, Hannun YA, Blenis J. FADD is
required for multiple signaling events downstream of the receptor Fas. Cell
Growth Differ. 1999 Dec;10(12):797-804. PMID: 10616904.


Lee-Fruman KK, Kuo CJ, Lippincott J, Terada N, Blenis J. Characterization of
S6K2, a novel kinase homologous to S6K1. Oncogene. 1999 Sep 9;18(36):5108-14.
PMID: 10490847.


Richards SA, Fu J, Romanelli A, Shimamura A, Blenis J. Ribosomal S6 kinase 1
(RSK1) activation requires signals dependent on and independent of the MAP kinase
ERK. Curr Biol. 1999 Jul 29-Aug 12;9(15):810-20. PMID: 10469565.


Romanelli A, Martin KA, Toker A, Blenis J. p70 S6 kinase is regulated by
protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated
signalling complex. Mol Cell Biol. 1999 Apr;19(4):2921-8. PMID: 10082559


Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC,
Blenis J, Greenberg ME. Akt promotes cell survival by phosphorylating and
inhibiting a Forkhead transcription factor. Cell. 1999 Mar 19;96(6):857-68.
PMID: 10102273.


Sánchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. Caspase-8 is required
for cell death induced by expanded polyglutamine repeats. Neuron. 1999
Mar;22(3):623-33. PMID: 10197541.


Juo P, Kuo CJ, Yuan J, Blenis J. Essential requirement for caspase-8/FLICE in
the initiation of the Fas-induced apoptotic cascade. Curr Biol. 1998 Sep
10;8(18):1001-8. PMID: 9740801.


Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA. pp90rsk1
regulates estrogen receptor-mediated transcription through phosphorylation of
Ser-167. Mol Cell Biol. 1998 Apr;18(4):1978-84. PMID: 9528769


Schinkmann K, Blenis J. Cloning and characterization of a human STE20-like
protein kinase with unusual cofactor requirements. J Biol Chem. 1997 Nov
7;272(45):28695-703. PMID: 9353338.


Chung J, Uchida E, Grammer TC, Blenis J. STAT3 serine phosphorylation by
ERK-dependent and -independent pathways negatively modulates its tyrosine
phosphorylation. Mol Cell Biol. 1997 Nov;17(11):6508-16. PMID: 9343414


Grammer TC, Blenis J. Evidence for MEK-independent pathways regulating the
prolonged activation of the ERK-MAP kinases. Oncogene. 1997 Apr
10;14(14):1635-42. PMID: 9135064.


Tung RM, Blenis J. A novel human SPS1/STE20 homologue, KHS, activates Jun
N-terminal kinase. Oncogene. 1997 Feb 13;14(6):653-9. PMID: 9038372.


Juo P, Kuo CJ, Reynolds SE, Konz RF, Raingeaud J, Davis RJ, Biemann HP,
Blenis J. Fas activation of the p38 mitogen-activated protein kinase signalling
pathway requires ICE/CED-3 family proteases. Mol Cell Biol. 1997 Jan;17(1):24-35.
Erratum in: Mol Cell Biol 1997 Mar;17(3):1757. PMID: 8972182


Watson KL, Chou MM, Blenis J, Gelbart WM, Erikson RL. A Drosophila gene
structurally and functionally homologous to the mammalian 70-kDa s6 kinase gene.
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13694-8. PMID: 8942996


Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA,
Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter
T, Cantley LC. A structural basis for substrate specificities of protein Ser/Thr
kinases: primary sequence preference of casein kinases I and II, NIMA,
phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1. Mol Cell
Biol. 1996 Nov;16(11):6486-93. PMID: 8887677


Grammer TC, Blenis J. The serine protease inhibitors, tosylphenylalanine
chloromethyl ketone and tosyllysine chloromethyl ketone, potently inhibit pp70s6k
activation. J Biol Chem. 1996 Sep 27;271(39):23650-2.PMID: 8798584.


Monfar M, Blenis J. Inhibition of p70/p85 S6 kinase activities in T cells by
dexamethasone. Mol Endocrinol. 1996 Sep;10(9):1107-15. PMID: 8885245.


Chou MM, Blenis J. The 70 kDa S6 kinase complexes with and is activated by
the Rho family G proteins Cdc42 and Rac1. Cell. 1996 May 17;85(4):573-83.
PMID: 8653792.


Chen RH, Juo PC, Curran T, Blenis J. Phosphorylation of c-Fos at the
C-terminus enhances its transforming activity. Oncogene. 1996 Apr
4;12(7):1493-502. PMID: 8622865.


Fisher TL, Blenis J. Evidence for two catalytically active kinase domains in
pp90rsk. Mol Cell Biol. 1996 Mar;16(3):1212-9. PMID: 8622665


Grammer TC, Cheatham L, Chou MM, Blenis J. The p70S6K signalling pathway: a
novel signalling system involved in growth regulation. Cancer Surv.
1996;27:271-92. PMID: 8909805.


Cheatham L, Monfar M, Chou MM, Blenis J. Structural and functional analysis
of pp70S6k. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11696-700. PMID:
8524831


Chou MM, Blenis J. The 70 kDa S6 kinase: regulation of a kinase with
multiple roles in mitogenic signalling. Curr Opin Cell Biol. 1995
Dec;7(6):806-14. Review. PMID: 8608011.


Monfar M, Lemon KP, Grammer TC, Cheatham L, Chung J, Vlahos CJ, Blenis J.
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is
mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol Cell
Biol. 1995 Jan;15(1):326-37. PMID: 7528328


Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. PDGF- and
insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH
kinase. Nature. 1994 Jul 7;370(6484):71-5. PMID: 8015612.


Blenis J, Resh MD. Subcellular localization specified by protein acylation
and phosphorylation. Curr Opin Cell Biol. 1993 Dec;5(6):984-9. Review.
PMID: 8129952.


Chen RH, Abate C, Blenis J. Phosphorylation of the c-Fos transrepression
domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase. Proc
Natl Acad Sci U S A. 1993 Dec 1;90(23):10952-6. PMID: 8248197


1Chen RH, Tung R, Abate C, Blenis J. Cytoplasmic to nuclear signal
transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase.
Biochem Soc Trans. 1993 Nov;21(4):895-900. Review. PMID: 8132089.


Blenis J. Signal transduction via the MAP kinases: proceed at your own RSK.
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5889-92. Review. PMID:
8392180


Kuo CJ, Chung J, Fiorentino DF, Flanagan WM, Blenis J, Crabtree GR.
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature.
1992 Jul 2;358(6381):70-3. PMID: 1614535.


Chung J, Kuo CJ, Crabtree GR, Blenis J. Rapamycin-FKBP specifically blocks
growth-dependent activation of and signaling by the 70 kd S6 protein kinases.
Cell. 1992 Jun 26;69(7):1227-36. PMID: 1377606.


Wood KW, Sarnecki C, Roberts TM, Blenis J. ras mediates nerve growth factor
receptor modulation of three signal-transducing protein kinases: MAP kinase,
Raf-1, and RSK. Cell. 1992 Mar 20;68(6):1041-50. PMID: 1312393.


Chen RH, Sarnecki C, Blenis J. Nuclear localization and regulation of erk-
and rsk-encoded protein kinases. Mol Cell Biol. 1992 Mar;12(3):915-27.
PMID: 1545823

Blenis J. Growth-regulated signal transduction by the MAP kinases and RSKs.
Cancer Cells. 1991 Nov;3(11):445-9. Review. PMID: 1662059.


Jurivich DA, Chung J, Blenis J. Heat shock induces two distinct S6 protein
kinase activities in quiescent mammalian fibroblasts. J Cell Physiol. 1991
Aug;148(2):252-9. PMID: 1880153.


Blenis J, Chung J, Erikson E, Alcorta DA, Erikson RL. Distinct mechanisms
for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase
signaling systems are indicated by inhibition of protein synthesis. Cell Growth
Differ. 1991 Jun;2(6):279-85. PMID: 1648378.


Chung J, Pelech SL, Blenis J. Mitogen-activated Swiss mouse 3T3 RSK kinases
I and II are related to pp44mpk from sea star oocytes and participate in the
regulation of pp90rsk activity. Proc Natl Acad Sci U S A. 1991 Jun
1;88(11):4981-5. PMID: 2052581


Chen RH, Chung J, Blenis J. Regulation of pp90rsk phosphorylation and S6
phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-,
and cyclic AMP-mediated signal transduction. Mol Cell Biol. 1991
Apr;11(4):1861-7. PMID: 1848664


Chung J, Chen RH, Blenis J. Coordinate regulation of pp90rsk and a distinct
protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk
in vitro. Mol Cell Biol. 1991 Apr;11(4):1868-74. PMID: 1826043


Chen RH, Blenis J. Identification of Xenopus S6 protein kinase homologs
(pp90rsk) in somatic cells: phosphorylation and activation during initiation of
cell proliferation. Mol Cell Biol. 1990 Jun;10(6):3204-15. PMID: 2342472;
 


Jones SW, Erikson E, Blenis J, Maller JL, Erikson RL. A Xenopus ribosomal
protein S6 kinase has two apparent kinase domains that are each similar to
distinct protein kinases. Proc Natl Acad Sci U S A. 1988 May;85(10):3377-81.
PMID: 3368449


Blenis J, Kuo CJ, Erikson RL. Identification of a ribosomal protein S6
kinase regulated by transformation and growth-promoting stimuli. J Biol Chem.
1987 Oct 25;262(30):14373-6. PMID: 2822690.


Blenis J, Erikson RL. Regulation of protein kinase activities in PC12
pheochromocytoma cells. EMBO J. 1986 Dec 20;5(13):3441-7. PMID: 3030727


Blenis J, Erikson RL. Stimulation of ribosomal protein S6 kinase activity by
pp60v-src or by serum: dissociation from phorbol ester-stimulated activity. Proc
Natl Acad Sci U S A. 1986 Mar;83(6):1733-7. PMID: 3081899


Blenis J, Erikson RL. Regulation of a ribosomal protein S6 kinase activity
by the Rous sarcoma virus transforming protein, serum, or phorbol ester. Proc
Natl Acad Sci U S A. 1985 Nov;82(22):7621-5. PMID: 3934663


Blenis J, Spivack JG, Erikson RL. Phorbol ester, serum, and rous sarcoma
virus transforming gene product induce similar phosphorylations of ribosomal
protein S6. Proc Natl Acad Sci U S A. 1984 Oct;81(20):6408-12. PMID:
6093101


Blenis J, Hawkes SP. Characterization of a transformation-sensitive protein
in the extracellular matrix of chicken embryo fibroblasts. J Biol Chem. 1984 Sep
25;259(18):11563-70. PMID: 6432799.


Blenis J, Erikson RL. Phosphorylation of the ribosomal protein S6 is
elevated in cells transformed by a variety of tumor viruses. J Virol. 1984
Jun;50(3):966-9. PMID: 6328026


Roff CF, Wozniak RW, Blenis J, Wang JL. The effect of mannose6-phosphate on
the turnover of cell surface glycosaminoglycans. Exp Cell Res. 1983 Apr
1;144(2):333-44. PMID: 6404644.


Blenis J, Hawkes SP. Transformation-sensitive protein associated with the
cell substratum of chicken embryo fibroblasts. Proc Natl Acad Sci U S A. 1983
Feb;80(3):770-4. PMID: 6298774


Steck PA, Blenis J, Voss PG, Wang JL. Growth control in cultured 3T3
fibroblasts II. Molecular properties of a fraction enriched in growth inhibitory
activity. J Cell Biol. 1982 Feb;92(2):523-30. PMID: 7061594